Generation of asymmetrical dimethylarginine in blood
نویسندگان
چکیده
منابع مشابه
Asymmetrical dimethylarginine: the Uber marker?
The traditional risk factors of hypercholesterolemia, hypertension, diabetes mellitus, and tobacco exposure identify a subset of patients at greater cardiovascular risk. A variety of clinical phenotypes, biochemical markers, and genetic polymorphisms have been proposed to explain the variance in risk not explained by the traditional factors. Notably, all of the traditional risk factors, as well...
متن کاملAsymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.
OBJECTIVE We explored the potential role of the endogenous NO synthase inhibitor asymmetrical dimethylarginine (ADMA) in patients with idiopathic pulmonary arterial hypertension (IPAH). Method and Results- We correlated plasma ADMA levels and cardiovascular indices from right heart catheterization in 57 patients with IPAH. Predictors of survival in patients with IPAH were studied. Furthermore, ...
متن کاملAsymmetrical dimethylarginine, oxidative stress, and atherosclerosis.
Asymmetrical Dimethylarginine, Oxidative Stress, and Atherosclerosis To the Editor: Antoniades et al1 reported on the role of asymmetrical dimethylarginine (ADMA) in inflammation-induced endothelial dysfunction in healthy subjects and in patients with coronary artery disease or rheumatoid arthritis. In patients with chronic inflammatory rheumatic diseases, serum nitrite concentrations were lowe...
متن کاملContribution of whole blood to the control of plasma asymmetrical dimethylarginine.
The endogenous nitric oxide (NO) synthase (NOS) inhibitor asymmetrical dimethylarginine (ADMA) is elevated in many patients and may contribute to the initiation and progression of their disease. While some mechanistic pathways have been identified, tissue-specific contributions to ADMA control remain unclear. We sought to determine if whole blood (WB) could participate in ADMA control ex vivo. ...
متن کاملExploring the role of dimethylarginine dimethylaminohydrolase-mediated reduction in tissue asymmetrical dimethylarginine levels in cardio-protective mechanism of ischaemic postconditioning in rats
Objective(s): Reperfusion of ischaemic myocardium results in reduced nitric oxide (NO) biosynthesis by endothelial nitric oxide synthase (eNOS) leading to endothelial dysfunction and subsequent tissue damage. Impaired NO biosynthesis may be partly due to increased levels of asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of eNOS. As dimethylarginine dimet...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a722-a